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Wayne Harding

Associate Professor
 
Department :
Chemistry
Membership :
Full Member
Core Research :
Neuro/Behavioral Science
Office :
Room 1321 CC North
Email :
Office Phone :
(212) 772-5359
Office Fax :
(212) 772-5332
Lab Room:
Room 1400 North
Education :
  • B.Sc., University of the West Indies, 1993
  • Ph.D.,University of the West Indies, 1999
  • Postdoc, University of Iowa, 2006
Research Interest :

Medicinal Chemistry and Natural Products Drug Discovery
My research interests encompass medicinal chemistry and natural products drug discovery with a special emphasis on the central nervous system (CNS) therapeutic area. Current projects involve the synthesis and SAR of analogues of CNS-active natural products as well as the isolation, semi-synthesis and SAR of compounds from plants possessing activity in the CNS

Selected Publications :
  • Aporphinoid Antagonists of 5-HT2A Receptors: Further Evaluation of Ring A Substituents and the Size of Ring C. Ponnala S, Kapadia N, Navarro HA, Harding WW. Chem Biol Drug Des. 2014 Apr 25. doi: 10.1111/cbdd.12345. [Epub ahead of print]
    PMID: 24766771
  • Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1664-7. doi: 10.1016/j.bmcl.2014.02.066. Epub 2014 Mar 4.
    PMID: 24630561
  • Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids. Kapadia N, Harding W. Tetrahedron. 2013 Oct 21;69(42). doi: 10.1016/j.tet.2013.07.095. PMID: 24187388
  • A New Route to Azafluoranthene Natural Products via Direct Arylation. Ponnala S, Harding WW. European J Org Chem. 2013 Feb 1;3013(6):1107-1115. Epub 2013 Jan 3. PMID: 23503080
  • Leonurenones A-C: Labdane diterpenes from Leonotis leonurus. He F, Lindqvist C, Harding WW. Phytochemistry. 2012 Nov;83:168-72. doi: 10.1016/j.phytochem.2012.07.014. Epub 2012 Aug 12. PMID: 22892215 [PubMed - indexed for MEDLINE]
  • New aporphinoid 5-HT2A antagonists by structural manipulations of nantenine. S. Chaudhary, S. Ponnala, O. LeGendre, J. A. Gonzales, H. A. Navarro and W. W. Harding. Bioorg. Med. Chem. 2011, 19, 5861-5868.
  • Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. S. Ponnala, S. Chaudhary, A. Gonzalez-Sarrias, N. P. Seeram and W. W. Harding. Bioorg. Med. Chem. Lett. 2011, 21, 4462.
  • Synthesis of C-homoaporphines via microwave-assisted direct arylation. S. Chaudhary and W. W. Harding Tetrahedron, 2011, 67, 569-575.
  • Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. S. Pecic, M. A. McAnuff and W. W. Harding. J. Enz. Inhib. and Med. Chem., 2011, 26, 46-55
  • Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies. S. Pecic, S. Chaudhary, P. Makkar, B. J. Reddy, H. A. Navarro and W. W. Harding Biorg. Med. Chem. 2010, 18, 5562-5575.
  • Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. O. LeGendre, Onica, S. Pecic, S. Chaudhary, S. M. Zimmerman, W. E. Fantegrossi, W.W. Harding Biorg. Med. Chem. Lett. 2010, 20, 628-631.
  • (±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners, S. Chaudhary, O. LeGendre, S. Pecic, H. A. Navarro, W. W. Harding Biorg. Med. Chem. Lett. 2009, 19, 2530-2532.
  • Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines. S. Chaudhary, O. LeGendre, S. Pecic, and W. W. Harding, Tet. Lett. 2009, 50, 2437-2439.
  • New drimane sesquiterpenoids from Tidestromia oblongifolia. S. Chaudhary, V. Thomas, L. Todaro, O. LeGendre, S. Pecic and W. W. Harding, Nat. Prod. Commun. 2008, 3, 1747-1750.
  • Herkinorin Analogues with Differential ? -Arrestin-2 Interactions. K. Tidgewell, C. E. Groer, W. W. Harding, A. Lozama, M. Schmidt, A. Marquam, J. Hiemstra, J. S. Partilla, C. M. Dersch, R. B. Rothman, L. Bohn, and T. E. Prisinzano, J. Med. Chem. 2008, 51,  2421-2431.
  • Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Preparation and Opioid Receptor Activity of Salvinicin Analogues. D. S, Simpson, P. L. Katavic, A. Lozama, W. W. Harding, D. Parrish, J. R. Deschamps, C. M. Dersch, J. S. Partilla, R. B. Rothman, H. Navarro, T. E. Prisinzano J. Med. Chem.  2007,  50,  3596-3603.