Michael W. Young, Ph.D.
Vice President for Academic Affairs Richard and Jeanne Fisher Professor
Laboratory of Genetics
REFRESHMENTS WILL BE SERVED
Supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health – 8 G12 MD007599-27 (formerly NCRR Grant #G12 RR003037) and grant #2UL1TR000457-06 (formerly grant #UL1RR024996) of the CTSC at Weill Cornell Medical College.
Abstract: Cyclin A (CycA) and Regulator of Cyclin A 1 (Rca1), genes essential for normal cell cycle progression, function in post-mitotic neurons to promote sleep in Drosophila melanogaster. Reducing the neuronal expression of either CycA or Rca1 delays the wake-sleep transition and causes multiple arousals from sleep. Furthermore, the homeostatic response to sleep deprivation is disrupted in these animals. CycA is expressed in ~40-50 neurons in the fly brain, most of which are intermingled with neurons known to regulate circadian behavioral rhythms. CycA+ neurons also appear to express the receptor for PDF, a neuropeptide that is rhythmically released by pacemaker cells, suggesting functional interactions among neurons controlling sleep and circadian behavior.
Denise Charles, CTBR
dc674 (at) hunter (dot) cuny (dot) edu