Benoit Chabot, Ph.D.
Professor, Director of the Research Center on RNA Biology and the Cancer Axis at the CRC Étienne-Lebel du CHUS Canada Research Chair in Functional Genomics Département de microbiologie et d'infectiologie Faculté de médecine et des sciences de la santé Université de Sherbrooke, Québec, Canada
REFRESHMENTS WILL BE SERVED
Supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health – 8 G12 MD007599-27 (formerly NCRR Grant #G12 RR003037) and grant #2UL1TR000457-06 (formerly grant #UL1RR024996) of the CTSC at Weill Cornell Medical College.
Abstract : Pre-mRNA alternative splicing (AS) constitutes a critical and flexible layer of regulation relevant to all biological processes. Alternative splicing profiles often change when cells are submitted to stress or develop into a tumor. Our results indicate that stress may kill a cell by disrupting a critical collaboration between hnRNP and SR proteins that normally prevents the production of a pro-apoptotic splice variant. We also identified hundreds of events that differentiate cancer from normal tissues. Many of these differences are driven by a drop in the expression of the splicing regulator RBFOX2 in cancer tissues. In addition, our results suggest that the architecture of transcripts is specifically redesigned in the tumor microenvironment to affect cancer development.
Ida K. Lang Recital Center, Room 424
Hunter North Hunter College
695 Park Avenue
(Enter on East 69th Street between Lexington and Park Avenue)
Denise Charles, CTBR
dc674 (at) hunter (dot) cuny (dot) edu