CTBR/Biology Department Seminar: Developmental maturation of astroglia and pathogenesis of neurodevelopmental disorders
Yongjie Yang, PhD
Department of Neurosciences, Tufts University, MA
Host: Maria Pereira
Abstract: Recent studies have implicated potentially significant roles for astrocytes in the pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation process following early differentiation from which typical morphology and important functions are acquired. Despite significant progress in understanding their early differentiation, very little is known about how astrocytes become functionally mature. In addition, whether functional maturation of astrocytes is disrupted in neurodevelopmental disorders and the consequences of this disruption remains essentially unknown. In my talk, I will present our study about how astrocyte developmental maturation is regulated, and how disruption of the astrocyte functional maturation process, especially alterations in their ability to regulate glutamate homeostasis, may alter synaptic physiology and contribute to the pathogenesis of neurodevelopmental disorders, particularly fragile x syndrome (FXS).
Supported by the Hunter College RCMI Program of the NIMHD/NIH (MD007599).
Light refreshments will be served at 11:45 am.
Conf. Rm. 926 Hunter North
Hunter College, CUNY