CTBR/Biology Department Seminar: Circulating Tumor Cell Biology: A Novel Approach for Elucidating the Mechanisms of Cancer Metastasis
Olorunseun O. Ogunwobi, MD, PhD
Department of Pathology,
Immunology & Laboratory Medicine
University of Florida
Abstract: Over 90% of all cancer deaths are caused by metastasis. The underlying mechanisms of cancer metastasis are unclear. However, it is known that the most common route is hematogenous dissemination. Hematogenous dissemination of cancer cells results in circulating tumor cells (CTCs). Metastasis is an inefficient process whereby majority of CTCs actually die. Therefore, specific molecular changes may be necessary for a subset of CTCs to remain viable and acquire metastatic capability. Consequently, understanding the biology of viable CTCs is a key to understanding the mechanisms of cancer metastasis. However, very little is currently known about CTC biology. In this presentation, establishment of novel CTC lines from a novel syngeneic orthotopic murine model of metastatic hepatocellular carcinoma will be described. Data demonstrating the uniqueness of the molecular profile and function of viable CTCs will be presented. This presentation will show the potential of this novel approach for discovery of novel insights into the mechanisms of cancer metastasis. There is also potential for this novel approach to ultimately lead to discovery of new molecular targets that can be exploited for early detection, prognostication, diagnosis, therapy and monitoring of therapy in a minimally-invasive fashion.
Refreshments will be served!
Supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health - 8 G12 MD007599-27 (formerly NCRR Grant #G12 RR003037)
Hunter College, CUNY
Biology Conference Room 926 HN
dc674 (at) hunter (dot) cuny (dot) edu