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CTBR/Biology Department Seminar: Biological Networks in Three Dimensions

Event Start Date: 
Wednesday, April 3, 2013 - 11:00am
Event End Date: 
Wednesday, April 3, 2013 - 12:00pm

Yu (Brandon) XIA, Ph.D
Assistant Professor, Program in Bioinformatics
Boston University

Recent advances in experimental proteomics have generated a wealth of data regarding proteins and protein-protein interactions in the native cellular environment. However, most proteomic analyses operate on a highly abstract level, treating proteins as nodes and protein-protein interactions as edges. Here, two studies are highlighted where three-dimensional modeling of protein networks within and between species provides insights into the biophysics and evolution of biological systems. First, a structural analysis of the yeast protein-protein interaction network reveals that protein evolution is constrained by the biophysics of protein folding, the mutational robustness of the native structure, and the biophysics and function of protein-protein interactions. Second, a structural analysis of human-virus proteinprotein
interaction networks reveals distinct principles governing antagonism versus cooperation in host-pathogen and within-host interactions.


Supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health - 8 G12 MD007599-27 (formerly NCRR Grant #G12 RR003037)


Hunter College, CUNY
Room 926HN
(69th Street, Between Lexington and Park Avenues)

Contact person and information for event: 

Denise Charles

dc674 (at) hunter (dot) cuny (dot) edu