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CTBR: Structural Evaluation of Fused Protein Domains for Therapeutic Relevance

Event Start Date: 
Wednesday, November 20, 2013 - 1:00pm
Event End Date: 
Wednesday, November 20, 2013 - 2:00pm
Description: 

Andreas Mbah, PhD

Bioinformatics and Genomics Specialist

Center for Bioinformatics & Computational Biology Department of Biology

Jackson State University

Abstract: The advances in the Next Generation Sequencing and Human Genome Projects provide opportunities to functionally evaluate the therapeutic relevance of proteins with clinical importance. The disease association of multidomain proteins that contain fused domains is well established. This form of biomolecular network is thus of therapeutic relevance. Structural and functional genomic tools are usually employed when studying drug targets or regulatory points encoded in protein sequences of therapeutic relevance. These large volumes of data generated from computational genomics have potential in translational research to address important questions in both basic biology and biomedicine. The talk will consist of two parts: (1) Part I: Structural and functional inferences on a GTP-binding protein with fused domains. Emphasis will be on my previous research which uses diverse structural bioinformatics tools to determine drug exploitable distinctive structural features of Smp_059340.1 protein. The Smp_058340.1 is a multidomain protein identified as an attractive drug target in Schistosoma mansoni genome; and (2) Part II: Proposed projects on computational and data-enabled translational research on minority health disparities. Genomic data generated from multidomain proteins and their associated biomolecular networks contain insightful information for (1) understanding the mechanism of biomolecular systems (2) diagnosis, treatment and drug design for diseases or disorders. Overall, the research works that will be highlighted and the proposed projects are part of the broad areas in translational research encountered in minority health disparities. These areas of research have potential for collaboration with diverse experts at Gene Center, nationally and internationally through an extramurally funded research programs.

Keywords: multidomain proteins, translational research, drug targets, minority health disparities, structural and functional genomics.

Refreshments will be served!

Supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health - 8 G12 MD007599-27

Location: 

Hunter College Biology Conference Room 926N

Contact person and information for event: 

Denise Charles (Gene Center) charles@genectr.hunter.cuny.edu