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Mitchell Goldfarb

Department :
Membership :
Associate Member
Core Research :
Neuro/Behavior Research
Office :
Email :
Office Phone :
Lab Room:
HN810 and HN805
Lab Web Site :
Education :
  • S.B., Massachusetts Institute of Technology, 1974
  • Ph.D., Massachusetts Institute of Technology,1979
  • Postdoc, Cold Spring Harbor Laboratories, 1980-1984
Research Interest :

Fibroblast growth factor homologous factors (FHFs) and their modulation of voltage-gated sodium channels: physical mechanisms, biological consequences in excitable cells, and disorders of brain and heart.

Selected Publications :

1)  Venkatesan K, Liu Y, Goldfarb M.  2014.  Fast-onset long-term open-state block of sodium channels by A-type FHFs mediates classical spike accommodation in hippocampal pyramidal neurons.  J. Neurosci. 34: 16126-16139.

2)  Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, Giza J, Tchetchik D, Kelley K, Vega A, Matthews GM, Rossi P, Ornitz DM, D'Angelo E.  2007.  Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.  Neuron 55: 449-463.

3)  Schoorlemmer J, Goldfarb M.  2001.  Fibroblast growth factor homologous factors are intracellular signaling proteins.  Curr. Biol. 11: 793-797.

4)  Feldman B, Poueymirou W, Papaionnou VE, DiChiara TM, Goldfarb M.  1994. Requirement of FGF-4 for postimplantation mouse development.  Science 267: 246-249.

5)  Zhan X, Bates B, Hu X, Goldfarb M.  1988.  The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.  Mol. Cell. Biol. 8: 3487-3495.

6)  Goldfarb M, Shimizu K, Perucho M, Wigler M.  1982.  Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells.  Nature 296: 404-409.


Link to publications on Google Scholar: