CTBR/Biology Department Seminar: Studies in Mice and Man: Understanding the Regulation of Brain Aging
Jeffrey Keller, PhD
Professor & Director
Institute for Dementia Research and Prevention
Hibernia National Bank/Edward G. Schlieder Chair
Pennington Biomedical Research Center
Louisiana State University
Host: Dr. Maria Figueiredo-Pereira
Alzheimer’s disease (AD) is the sixth leading cause of death in the United States and currently has no disease-modifying medications. Aging is the biggest risk factor for numerous neurodegenerative disorders including AD, although we know remarkably little in terms of the mechanisms by which aging contributes to the development of these disorders. Given that 10,000 people turn 65 in the United States each day, there is an urgent need to understand the basis of brain aging and to prevent the causes of age-related disorders including AD.
More than 65% of Americans are overweight or obese, and this is expected to have dramatic and negative effects across the spectrum of health and healthcare. We are only beginning to understand the complex interactions between aging and obesity, although it is clear that the interplay between these two factors is critical to the regulation of brain aging and development of dementia.
In order to understand the regulation of brain aging, it is clear that we will need to utilize a variety of research tools and research models, develop new ways of studying aging, and perhaps formulate new hypotheses. We will almost certainly need to incorporate similar changes in the research of AD and related disorders if we are to ever develop treatments or disease-modifying medications for AD. The focus of this seminar will be to provide an overview of each of these issues, describe our current research efforts, and carefully highlight the research problems/areas that need to be addressed in future brain aging and AD research.
Conf. Rm. 926 Hunter North
Denise Charles, CTBR
dc674 (at) hunter (dot) cuny (dot) edu