Prostate cancer (PCa) is frequently diagnosed in men worldwide, but the incidence and mortality rates of aggressive PCa is disproportionately higher in men of African descent. Multiple independent genome wide association studies (GWAS) have identified chromosome 8q24 as a PCa susceptibility locus. And some studies have associated chromosome 8q24 with aggressive PCa in men of African descent. Chromosome 8q24 contains one protein-coding gene (c-Myc), and multiple non-protein coding genes. It is well known that only a subset of PCa patients have aberrations of c-Myc. Consequently, the Ogunwobi laboratory at Hunter College has been investigating the hypothesis that one or more of the non-protein coding genes at chromosome 8q24 may play a role in PCa especially in men of African descent. We have focused on the gene that encodes the long non coding RNA (ncRNA), PVT1. PVT1 has been shown to be overexpressed in PCa. However, PVT1 was not previously well-characterized. Recently, we identified at least twelve separate exons of PVT1. And using a panel of nine human PCa cell lines modeling various clinical characteristics of PCa including race, we observed that the twelve exons of PVT1 are differentially expressed. In particular, exon 9 of PVT1 is reproducibly and significantly overexpressed in aggressive PCa cell lines derived from Black men. PVT1 also encodes six annotated miRNAs. However, the role of the PVT1-encoded miRNAs in PCa was previously unknown. We have discovered that two of these PVT1-encoded miRNAs, miR-1205 and miR-1207-3p, are significantly underexpressed in PCa cell lines. In ongoing studies in the Ogunwobi laboratory at Hunter College, we are progressively characterizing the role of these PVT1-derived ncRNAs in PCa.